Potential risk factors included the total number of instances of vaginal intercourse (continuous variable), the number of new partners (0, 1, or >1), the frequency of condom use by partners (<5 percent, 5 to 49 percent, 50 to 99 percent, or 100 percent), the partner's circumcision status (circumcised, uncircumcised, or unknown), and the partner's number of previous partners (0, ?1, or unknown). The frequency of condom use was calculated by dividing the number of condoms used for vaginal intercourse by the number of instances of vaginal intercourse during the eight-month study period. If multiple new partners were reported during an eight-month period, the circumcision status and previous number of partners were summarized ( Table 1 ). The percentage of days that lacked diary entries was calculated to assess potential confounding created by missing data. The effect of the frequency of condom use was evaluated by multivariate analysis with the inclusion of other variables that were found to be significant (P<0.10) in univariate analyses. Similar analyses were performed to evaluate risk factors for high-risk types of HPV (16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 73, and 82), 20,21 low-risk types (6, 11, 40, 42, 54, 55, 57, 61, 62, 64, 69, 70, 71, 72, 81, 83, 84, and CP6108), 20,21 and types 6, 11, 16, and 18 (which are included in quadrivalent vaccine trials 22 ). To evaluate whether the effect of condom use on the risk of HPV infection differed according to the location in the genital tract, similar analyses were performed to examine risk factors for incident cervical and vulvovaginal infections.
Inside the subanalyses, subjects whoever couples made use of condoms 100 % of the time was indeed split into one or two groups on the basis of the answers to help you issue “Performed your partner’s cock actually ever touching the opening of the genitals in place of good condom?” In the event that victims always responded “no” for each and every act out of vaginal intercourse for the 7-day several months, these were coded as the with had “zero genital contact rather than a condom.” Analyses was indeed performed because demonstrated significantly more than, which have four kinds of the fresh new regularity from condom use (100 % without having any genital contact rather than a beneficial condom, completely which includes otherwise an unknown frequency of vaginal get in touch with without an effective condom, and you will around three communities less than 100 %, because explained a lot more than) Swinger Sites dating only consumer reports.
Likewise, Cox proportional-potential risks patterns were utilized to determine exposure issues towards the recognition off experience cervical squamous intraepithelial sores into the seven days just before a given Pap try (based on an earlier observance that most sores exist soon after incident disease 23 ). A beneficial 51-time lag before each see are provided while the 51 months was the new quickest noticed period between your date a lady first got intercourse plus the go out from identification away from a situation lesion inside this research. Investigation to have such as victims was censored following the first identification regarding an instance lesion.
Overall performance
The fresh new mean (±SD) age the fresh new 82 subjects at the enrollment try 19.3±0.eight many years. The subjects complete 709 check outs. The brand new mean follow-upwards go out is 33.9±eleven.8 months, this new mean level of check outs for every single woman was 8.6±2.9, and also the median time taken between visits are 4.step 1 months. Journal studies was 90.7 percent complete, and you can condom study were recorded toward 99.step three percent from weeks you to gender are claimed.
Table dos
The fresh new twelve-few days cumulative chance from an initial HPV disease just after earliest sex is 37.dos % (95 % count on interval, twenty-seven.2 in order to 49.cuatro per cent). All in all, 126 event variety of-specific infection were known when you look at the 40 girls when they very first got sex ( Table 2 ). Incident infection was indeed identified inside around three lady prior to they reported that have gender the very first time, and you to definitely self-confident to possess HPV types of 51, you to definitely getting HPV particular six, plus one for HPV types forty, 61, and you will 66. The latest 24-times cumulative frequency out-of cervical squamous intraepithelial lesions are fifteen.0 percent (95 % rely on interval, 8.3 in order to twenty six.2 %).
